Abaloparatide is a bone density conservation agent indicated for the treatment of osteoporosis in postmenopausal women at high risk for vertebral and/or non-vertebral fractures. It is a PTH1 receptor (PTH1R) agonist that activates the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in bone mineral density (BMD) and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral sites.
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