Acenocoumarol is used for short-term anticoagulation needs but is not approved for use in the USA. Similar to other coumarin derivatives, the anticoagulant effects of acenocoumarol are mediated via inhibition of vitamin K epoxide reductase, which impairs gamma carboxylation of glutamic acid residues of the precursor proteins of factors II, VII, IX, and X.
Why do you need an Acenocoumarol monograph?
Superior Toxicology and Wellness’s monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs)
- The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
- A listing of all cited references utilized in the derivation of the OEL and ADE
- An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA’s Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities
Benefits of Superior Toxicology and Wellness monographs:
- Full drug documentation. The report consists of 10-12 pages in length, with calculations and cited references.
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