Acetylcysteine is indicated for the treatment of mucous formation and accumulation in the lungs and acetaminophen overdose. Acetylcysteine as mucolytic agent – The viscosity of mucous secretions in the lung depends on the concentrations of protein and to a lesser extent deoxyribonucleic acid (DNA). The latter increases with increasing puss caused by cellular debris. The mucolytic action of acetylcysteine is related to the sulfhydryl group in the molecule. This group probably “opens” disulfide linkages in mucous thereby lowering the viscosity.

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Superior Toxicology and Wellness’s monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs)

• The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
• A listing of all cited references utilized in the derivation of the OEL and ADE
• An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA’s Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

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